Clinical Cytogenetics and Genetics

Breeding and Genetics CYTOGENETICS OF SUGARCANE

The progress in the cytogenetics of sugarcane with special reference to researches during the last decade is reviewed. Standardisation of leaf squash, pollen grain squash and root t ip squash methods for chromosome study have been reported. Culturing of pollen grains and cells in vitro have been new additions. The basic chromosome number of Saccharum may be 5, 6, 8 and 10. A new line of investi...

Genetics, Cytogenetics, and Epigenetics of Colorectal Cancer

Most of the colorectal cancer (CRC) cases are sporadic, only 25% of the patients have a family history of the disease, and major genes causing syndromes predisposing to CRC only account for 5-6% of the total cases. The following subtypes can be recognized: MIN (microsatellite instability), CIN (chromosomal instability), and CIMP (CpG island methylator phenotype). CIN occurs in 80-85% of CRC. Ch...

Atlas of Genetics and Cytogenetics in Oncology

The BIN1 gene encodes a set of BAR adapter proteins generated by alternate RNA splicing which function in membrane and actin dynamics, cell polarity and stress signaling. In cancer cells, BIN1 functions as a tumor suppressor gene and it is commonly silenced or misspliced during malignant progression. Genetic investigations in fission yeast, flies, mice and human cells suggest that BIN1 adapter ...

Atlas of Genetics and Cytogenetics in Oncology

Atlas of Genetics and Cytogenetics in

Oral presentation Homozygous deletions are often seen in cancer as a means of inactivating tumour suppressor genes. However, such deletions can also result from genome instability and as such probably represent passenger events that do not contribute to carcinogenesis. These passenger deletions are often associated with known regions of genomic fragility (fragile sites). We have analysed approx...